Monday, December 31, 2012

Top 5 Rejection Reasons for Auto Insurance Claim


Dallas Auto InsuranceAuto insurance is meant to protect a person?s financial stability if they?re ever in a motor vehicle accident.? Unfortunately, just like any other type of insurance, these claims can be denied.? When this occurs, it can leave a driver on the hook for an excessive amount of money.? This makes it imperative for every driver to understand the most common reasons car insurance claims are denied.?

Lapsed Policy

Lapsed Dallas Auto Insurance?policies are one of the most common reasons that a claim will be denied.? This can be a simple mistake on the part of a driver.? Most people have trouble remembering everything in their daily lives, but failing to pay their motor vehicle insurance premium can be far more detrimental than other mistakes.? It?s often a good idea to set up an automatic payment plan to avoid this.?

Damages exceed Coverage

Everyone has seen the commercials on television that offer people the option of state minimum coverage auto insurance.? Unfortunately, this can leave drivers in hot water.? If a person only has $15,000 in property damage coverage but their accident causes $50,000, that driver must find a way to pay the other $35,000 themselves.? This can financially ruin a person.?

Driver not on Policy

Many people believe that their car insurance policy will cover anyone who drives their vehicle, but this is definitely not the case.? A driver who isn?t on a person?s car insurance policy is basically an unknown risk to the insurance company, and they aren?t in the business of providing protection for risks that they cannot foresee.? If someone who isn?t on the insurance policy is involved in a wreck, the company will likely pay nothing.?

Oversights? ? ? ? ? ? ??

Another of the most common reasons for car insurance claim denials is simple oversights.? A person who files an uninsured motorist claim, for instance, will likely be denied if the other driver did have some form of insurance.? These mistakes seem simple, but they can be incredibly time consuming and damaging.?

Inaccurate Information

A fifth common reason for car insurance claim denials is inaccurate information on the policy.? A person who is listed on their policy as living in one area who is really living in another, for instance, creates another unknown risk for an auto insurance company.? Any information that is inaccurate on a policy can cause issues for the insurance company and the policyholder, but mostly for the policyholder.? This makes it imperative to always update information on a policy as it changes.?

Any of the aforementioned reasons can cause a person?s auto insurance claim to be denied.? This is unfortunate considering the fact that all of these instances can easily be avoided.? It?s important for all drivers to understand everything about their policies and to keep them as up to date as possible.? This will ensure that there are no unexpected surprises after the filing of a claim.?

If you want to avoid these common causes of car insurance claim denials, call an All About Insurance agent today at (817) 589-0006 and we can help you out.?

Posted Saturday, December 29 2012 8:54 PM
Tags : dallas, TX, texas, auto, insurance, claim, damage, coverage, policy

Source: http://www.allaboutins.com/blog/top_5_rejection_reasons_for_auto_insurance_claim.aspx

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Friday, December 28, 2012

This is the Modem World: Things we'll be returning

Each week Joshua Fruhlinger contributes This is the Modem World, a column dedicated to exploring the culture of consumer technology.

DNP This is the Modem World Things we'll be returning

We're the family techies. The nerds. The ones who answer all your questions at family holiday gatherings about setting up new tablets and killing viruses. And it's sweet of you to buy us gadgets, but the chances of you getting us something that we don't already have and something that we actually want are, honestly, slim. So we take the gifts, say "How did you know?" and quietly return them for things we actually want. Don't take it personally. It's just that we kinda know what we're doing when it comes to ones and zeros.

Therefore, I present to you the things we will be returning this week. And if you're the friend or loved one of a propeller head, perhaps this will help you next year.

Continue reading This is the Modem World: Things we'll be returning

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/WAr_kZY7pp4/

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Picture of the day: Junior dos Santos shows why holding pads for him is no fun

UFC heavyweight champion Junior dos Santos will put his title on the line at UFC 155 this weekend. He got in some training outside his hotel on Christmas, and his partner showed why holding pads for such a hard hitter is not an easy job. He is wearing padding all over, and do you blame him?

Source: http://sports.yahoo.com/blogs/mma-cagewriter/picture-day-junior-dos-santos-shows-why-holding-232450809--mma.html

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Wednesday, December 26, 2012

Winter storms, tornado threats for Christmas in US

NEW ORLEANS (AP) ? Forecasts of snow, sleet and freezing rain threatened to complicate Christmas Day travel around the nation's midsection Tuesday as several Gulf Coast states braced for a chance of twisters and powerful thunderstorms.

A blizzard watch was posted for parts of Indiana and western Kentucky for storms expected to develop Tuesday amid predictions of up to 4 to 7 inches of snow in coming hours. Much of Oklahoma and Arkansas braced under a winter storm warning of an early mix of rain and sleet later turning to snow.

Some mountainous areas of Arkansas' Ozark Mountains could get up to 10 inches of snow amid warnings travel could become "very hazardous or impossible" in the northern tier of the state from near whiteout conditions, the National Weather Service said.

Early Tuesday, the Oklahoma Department of Public Safety said some bridges and overpasses were already becoming slick. Also, Kathleen O'Shea with Oklahoma Gas and Electric said the utility was tracking the storm system to see where repair crews might be needed among nearly 800,000 customers in Oklahoma and western Arkansas.

Elsewhere, areas of east Texas and Louisiana braced for possible thunderstorms as forecasters eyed a swath of the Gulf Coast from east Texas to the Florida Panhandle for the threat of any tornadoes.

Storms expected during the day Tuesday along the Gulf Coast could bring strong tornadoes or winds of more than 75 mph, heavy rain, quarter-sized hail and dangerous lightning in Louisiana and Mississippi, the weather service said.

"Please plan now for how you will receive a severe weather warning, and know where you will go when it is issued. It only takes a few minutes, and it will help everyone have a safe Christmas," Mississippi Gov. Phil Bryant said.

Ten storm systems in the last 50 years have spawned at least one Christmastime tornado with winds of 113 mph or more in the South, said Chris Vaccaro, a National Weather Service spokesman in Washington, via email.

The most lethal were the storms of Dec. 24-26, 1982, when 29 tornadoes in Oklahoma, Missouri, Arkansas, Tennessee and Mississippi killed three people and injured 32; and those of Dec. 24-25, 1964, when two people were killed and about 30 people injured by 14 tornadoes in seven states.

In Alabama, the director of the Emergency Management Agency, Art Faulkner, said he has briefed both local officials and Gov. Robert Bentley on plans for dealing with a possible outbreak of storms.

No day is good for severe weather, but Faulkner said Christmas adds extra challenges because people are visiting unfamiliar areas and often thinking more of snow than possible twisters.

"We are trying to get the word out through our media partners and through social media that people need to be prepared," Faulkner said

During the night, flog blanketed highways at times in the Southeast, including arteries in Atlanta where motorists slowed as a precaution. Fog advisories were posted from Alabama through the Carolinas into southwestern Virginia.

Several communities in Louisiana went ahead with the annual Christmas Eve lighting more than 100 towering log teepees for annual bonfires to welcome Pere Noel along the Mississippi River between New Orleans and Baton Rouge. That decision came after fire chiefs and local officials decided to go ahead with the tradition after an afternoon conference call with the National Weather Service.

In California, after a brief reprieve across the northern half of the state on Monday, wet weather was expected to make another appearance on Christmas Day. Flooding and snarled holiday traffic were expected in Southern California.

___

Associated Press writer Bob Johnson in Montgomery, Ala., and Ken Miller in Oklahoma City, Okla., contributed to this report.

Source: http://news.yahoo.com/winter-storms-tornado-threats-christmas-us-093157279.html

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Monday, December 24, 2012

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If you?re encountered with biology syllabus assessment in that case he/she really needs to fully grasp the exact objectives to make sure that he/she are able to comprehend the objective. There are 3 well-known objectives concerning learning the field of biology which generally are to have practical knowledge with understanding, ability to actually deal with important information and resolve issues in conjunction with learning experimental skillsets as well as inspections.

The actual Biology Syllabus entails of scientific phenomena specifics hence these particular 3 important objectives are crucial for the main assessment procedure. A few other reasons for assessment are to be capable of making predictions, address issues, manipulate data and locate ideal sources to get knowledge acquisition.

19 December 2012 | Reference and Education

Source: http://www.apodimosstudents.com/reference-and-education/biology-syllabus-so-what-does-the-subject-focused-on/

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Friday, December 21, 2012

AP IMPACT: Steroids loom in major-college football

WASHINGTON (AP) ? With steroids easy to buy, testing weak and punishments inconsistent, college football players are packing on significant weight ? 30 pounds or more in a single year, sometimes ? without drawing much attention from their schools or the NCAA in a sport that earns tens of billions of dollars for teams.

Rules vary so widely that, on any given game day, a team with a strict no-steroid policy can face a team whose players have repeatedly tested positive.

An investigation by The Associated Press ? based on dozens of interviews with players, testers, dealers and experts and an analysis of weight records for more than 61,000 players ? revealed that while those running the multibillion-dollar sport believe the problem is under control, that is hardly the case.

The sport's near-zero rate of positive steroids tests isn't an accurate gauge among college athletes. Random tests provide weak deterrence and, by design, fail to catch every player using steroids. Colleges also are reluctant to spend money on expensive steroid testing when cheaper ones for drugs like marijuana allow them to say they're doing everything they can to keep drugs out of football.

"It's nothing like what's going on in reality," said Don Catlin, an anti-doping pioneer who spent years conducting the NCAA's laboratory tests at UCLA. He became so frustrated with the college system that it drove him in part to leave the testing industry to focus on anti-doping research.

Catlin said the collegiate system, in which players often are notified days before a test and many schools don't even test for steroids, is designed to not catch dopers. That artificially reduces the numbers of positive tests and keeps schools safe from embarrassing drug scandals.

While other major sports have been beset by revelations of steroid use, college football has operated with barely a whiff of scandal. Between 1996 and 2010 ? the era of Barry Bonds, Mark McGwire, Marion Jones and Lance Armstrong ? the failure rate for NCAA steroid tests fell even closer to zero from an already low rate of less than 1 percent.

The AP's investigation, drawing upon more than a decade of official rosters from all 120 Football Bowl Subdivision teams, found thousands of players quickly putting on significant weight, even more than their fellow players. The information compiled by the AP included players who appeared for multiple years on the same teams, making it the most comprehensive data available.

For decades, scientific studies have shown that anabolic steroid use leads to an increase in body weight. Weight gain alone doesn't prove steroid use, but very rapid weight gain is one factor that would be deemed suspicious, said Kathy Turpin, senior director of sport drug testing for the National Center for Drug Free Sport, which conducts tests for the NCAA and more than 300 schools.

Yet the NCAA has never studied weight gain or considered it in regard to its steroid testing policies, said Mary Wilfert, the NCAA's associate director of health and safety. She would not speculate on the cause of such rapid weight gain.

The NCAA attributes the decline in positive tests to its year-round drug testing program, combined with anti-drug education and testing conducted by schools.

"The effort has been increasing, and we believe it has driven down use," Wilfert said.

Big gains, data show

The AP's analysis found that, regardless of school, conference and won-loss record, many players gained weight at exceptional rates compared with their fellow athletes and while accounting for their heights. The documented weight gains could not be explained by the amount of money schools spent on weight rooms, trainers and other football expenses.

Adding more than 20 or 25 pounds of lean muscle in a year is nearly impossible through diet and exercise alone, said Dan Benardot, director of the Laboratory for Elite Athlete Performance at Georgia State University.

The AP's analysis corrected for the fact that players in different positions have different body types, so speedy wide receivers weren't compared to bulkier offensive tackles. It could not assess each player's physical makeup, such as how much weight gain was muscle versus fat, one indicator of steroid use. In the most extreme case in the AP analysis, the probability that a player put on so much weight compared with other players was so rare that the odds statistically were roughly the same as an NFL quarterback throwing 12 passing touchdowns or an NFL running back rushing for 600 yards in one game.

In nearly all the rarest cases of weight gain in the AP study, players were offensive or defensive linemen, hulking giants who tower above 6-foot-3 and weigh 300 pounds or more. Four of those players interviewed by the AP said that they never used steroids and gained weight through dramatic increases in eating, up to six meals a day. Two said they were aware of other players using steroids.

"I just ate. I ate 5-6 times a day," said Clint Oldenburg, who played for Colorado State starting in 2002 and for five years in the NFL. Oldenburg's weight increased over four years from 212 to 290, including a one-year gain of 53 pounds, which he attributed to diet and two hours of weight lifting daily. "It wasn't as difficult as you think. I just ate anything."

Oldenburg told the AP he was surprised at the scope of steroid use in college football, even in Colorado State's locker room. "College performance enhancers were more prevalent than I thought," he said. "There were a lot of guys even on my team that were using." He declined to identify any of them.

The AP found more than 4,700 players ? or about 7 percent of all players ? who gained more than 20 pounds overall in a single year. It was common for the athletes to gain 10, 15 and up to 20 pounds in their first year under a rigorous regimen of weightlifting and diet. Others gained 25, 35 and 40 pounds in a season. In roughly 100 cases, players packed on as much 80 pounds in a single year.

In at least 11 instances, players that AP identified as packing on significant weight in college went on to fail NFL drug tests. But pro football's confidentiality rules make it impossible to know for certain which drugs were used and how many others failed tests that never became public.

What is bubbling under the surface in college football, which helps elite athletes gain unusual amounts of weight? Without access to detailed information about each player's body composition, drug testing and workout regimen, which schools do not release, it's impossible to say with certainty what's behind the trend. But Catlin has little doubt: It is steroids.

"It's not brain surgery to figure out what's going on," he said. "To me, it's very clear."

Football's most infamous steroid user was Lyle Alzado, who became a star NFL defensive end in the 1970s and '80s before he admitted to juicing his entire career. He started in college, where the 190-pound freshman gained 40 pounds in one year. It was a 21 percent jump in body mass, a tremendous gain that far exceeded what researchers have seen in controlled, short-term studies of steroid use by athletes. Alzado died of brain cancer in 1992.

The AP found more than 130 big-time college football players who showed comparable one-year gains in the past decade. Students posted such extraordinary weight gains across the country, in every conference, in nearly every school. Many of them eclipsed Alzado and gained 25, 35, even 40 percent of their body mass.

Even though testers consider rapid weight gain suspicious, in practice it doesn't result in testing. Ben Lamaak, who arrived at Iowa State in 2006, said he weighed 225 pounds in high school and 262 pounds in the summer of his freshman year on the Cyclones football team. A year later, official rosters showed the former basketball player from Cedar Rapids weighed 306, a gain of 81 pounds since high school. He graduated as a 320-pound offensive lineman and said he did it all naturally.

"I was just a young kid at that time, and I was still growing into my body," he said. "It really wasn't that hard for me to gain the weight. I had fun doing it. I love to eat. It wasn't a problem."

In addition to random drug testing, Iowa State is one of many schools that have "reasonable suspicion" testing. That means players can be tested when their behavior or physical symptoms suggest drug use.

Despite gaining 81 pounds in a year, Lamaak said he was never singled out for testing.

The associate athletics director for athletic training at Iowa State, Mark Coberley, said coaches and trainers use body composition, strength data and other factors to spot suspected cheaters. Lamaak, he said, was not suspicious because he gained a lot of "non-lean" weight.

"There are a lot of things that go into trying to identify whether guys are using performance-enhancing drugs," Coberley said. "If anybody had the answer, they'd be spotting people that do it. We keep our radar up and watch for things that are suspicious and try to protect the kids from making stupid decisions."

There's no evidence that Lamaak's weight gain was anything but natural. Gaining fat is much easier than gaining muscle. But colleges don't routinely release information on how much of the weight their players gain is muscle, as opposed to fat. Without knowing more, said Benardot, the expert at Georgia State, it's impossible to say whether large athletes were putting on suspicious amounts of muscle or simply obese, which is defined as a body mass index greater than 30.

Looking solely at the most significant weight gainers also ignores players like Bryan Maneafaiga.

In the summer of 2004, Maneafaiga was an undersized 180-pound running back trying to make the University of Hawaii football team. Twice ? once in pre-season and once in the fall ? he failed school drug tests, showing up positive for marijuana use. What surprised him was that the same tests turned up negative for steroids.

He'd started injecting stanozolol, a steroid, in the summer to help bulk up to a roster weight of 200 pounds. Once on the team, where he saw only limited playing time, he'd occasionally inject the milky liquid into his buttocks the day before games.

"Food and good training will only get you so far," he told the AP recently.

Maneafaiga's coach, June Jones, meanwhile, said none of his players had tested positive for doping since he took over the team in 1999. He also said publicly that steroids had been eliminated in college football: "I would say 100 percent," he told The Honolulu Advertiser in 2006.

Jones said it was news to him that one of his players had used steroids. Jones, who now coaches at Southern Methodist University, said many of his former players put on bulk working hard in the weight room. For instance, adding 70 pounds over a three- to four-year period isn't unusual, he said.

Jones said a big jump in muscle year-over-year ? say 40 pounds ? would be a "red light that something is not right."

Jones, a former NFL head coach, said he is unaware of any steroid use at SMU and believes the NCAA is doing a good job testing players. "I just think because the way the NCAA regulates it now that it's very hard to get around those tests," he said.

The cost of testing

While the use of drugs in professional sports is a question of fairness, use among college athletes is also important as a public policy issue. That's because most top-tier football teams are from public schools that benefit from millions of dollars each year in taxpayer subsidies. Their athletes are essentially wards of the state. Coaches and trainers ? the ones who tell players how to behave, how to exercise and what to eat ? are government employees.

Then there are the health risks, which include heart and liver problems and cancer.

On paper, college football has a strong drug policy. The NCAA conducts random, unannounced drug testing and the penalties for failure are severe. Players lose an entire year of eligibility after a first positive test. A second offense means permanent ineligibility from sports.

In practice, though, the NCAA's roughly 11,000 annual tests amount to just a fraction of all athletes in Division I and II schools. Exactly how many tests are conducted each year on football players is unclear because the NCAA hasn't published its data for two years. And when it did, it periodically changed the formats, making it impossible to compare one year of football to the next.

Even when players are tested by the NCAA, people involved in the process say it's easy enough to anticipate the test and develop a doping routine that results in a clean test by the time it occurs. NCAA rules say players can be notified up to two days in advance of a test, which Catlin says is plenty of time to beat a test if players have designed the right doping regimen. By comparison, Olympic athletes are given no notice.

"Everybody knows when testing is coming. They all know. And they know how to beat the test," Catlin said, adding, "Only the really dumb ones are getting caught."

Players are far more likely to be tested for drugs by their schools than by the NCAA. But while many schools have policies that give them the right to test for steroids, they often opt not to. Schools are much more focused on street drugs like cocaine and marijuana. Depending on how many tests a school orders, each steroid test can cost $100 to $200, while a simple test for street drugs might cost as little as $25.

When schools call and ask about drug testing, the first question is usually, "How much will it cost," Turpin said.

Most schools that use Drug Free Sport do not test for anabolic steroids, Turpin said. Some are worried about the cost. Others don't think they have a problem. And others believe that since the NCAA tests for steroids their money is best spent testing for street drugs, she said.

Wilfert, the NCAA official, said the possibility of steroid testing is still a deterrent, even at schools where it isn't conducted.

"Even though perhaps those institutional programs are not including steroids in all their tests, they could, and they do from time to time," she said. "So, it is a kind of deterrence."

For Catlin, one of the most frustrating things about running the UCLA testing lab was getting urine samples from schools around the country and only being asked to test for cocaine, marijuana and the like.

"Schools are very good at saying, 'Man, we're really strong on drug testing,'" he said. "And that's all they really want to be able to say and to do and to promote."

That helps explain how two school drug tests could miss Maneafaiga's steroid use. It's also possible that the random test came at an ideal time in Maneafaiga's steroid cycle.

Enforcement varies

The top steroid investigator at the U.S. Drug Enforcement Administration, Joe Rannazzisi, said he doesn't understand why schools don't invest in the same kind of testing, with the same penalties, as the NFL. The NFL has a thorough testing program for most drugs, though the league has yet to resolve a long-simmering feud with its players union about how to test for human growth hormone.

"Is it expensive? Of course, but college football makes a lot of money," he said. "Invest in the integrity of your program."

For a school to test all 85 scholarship football players for steroids twice a season would cost up to $34,000, Catlin said, plus the cost of collecting and handling the urine samples. That's about 0.2 percent of the average big-time school football budget of about $14 million. Testing all athletes in all sports would make the school's costs higher.

When schools ask Drug Free Sport for advice on their drug policies, Turpin said she recommends an immediate suspension after the first positive drug test. Otherwise, she said, "student athletes will roll the dice."

But drug use is a bigger deal at some schools than others.

At Notre Dame and Alabama, the teams that will soon compete for the national championship, players don't automatically miss games for testing positive for steroids. At Alabama, coaches have wide discretion. Notre Dame's student-athlete handbook says a player who fails a test can return to the field once the steroids are out of his system.

"If you're a strength-and-conditioning coach, if you see your kids making gains that seem a little out of line, are you going to say, 'I'm going to investigate further? I want to catch someone?'" said Anthony Roberts, an author of a book on steroids who says he has helped college football players design steroid regimens to beat drug tests.

There are schools with tough policies. The University of North Carolina kicks players off the team after a single positive test for steroids. Auburn's student-athlete handbook calls for a half-season suspension for any athlete caught using performance-enhancing drugs.

Wilfert said it's not up to the NCAA to determine whether that's fair.

"Obviously if it was our testing program, we believe that everybody should be under the same protocol and the same sanction," she said.

Fans typically have no idea that such discrepancies exist and players are left to suspect who might be cheating.

"You see a lot of guys and you know they're possibly on something because they just don't gain weight but get stronger real fast," said Orrin Thompson, a former defensive lineman at Duke. "You know they could be doing something but you really don't know for sure."

Thompson gained 85 pounds between 2001 and 2004, according to Duke rosters and Thompson himself. He said he did not use steroids and was subjected to several tests while at Duke, a school where a single positive steroid test results in a yearlong suspension.

Meanwhile at UCLA, home of the laboratory that for years set the standard for cutting-edge steroid testing, athletes can fail three drug tests before being suspended. At Bowling Green, testing is voluntary.

At the University of Maryland, students must get counseling after testing positive, but school officials are prohibited from disciplining first-time steroid users. Athletic department spokesman Matt Taylor denied that was the case and sent the AP a copy of the policy. But the policy Taylor sent included this provision: "The athletic department/coaching staff may not discipline a student-athlete for a first drug offense."

By comparison, in Kentucky and Maryland, racehorses face tougher testing and sanctions than football players at Louisville or the University of Maryland.

"If you're trying to keep a level playing field, that seems nonsensical," said Rannazzisi at the DEA. He said he was surprised to learn that what gets a free pass at one school gets players immediately suspended at another. "What message does that send? It's OK to cheat once or twice?"

Only about half the student athletes in a 2009 NCAA survey said they believed school testing deterred drug use.

As an association of colleges and universities, the NCAA could not unilaterally force schools to institute uniform testing policies and sanctions, Wilfert said.

"We can't tell them what to do, but if went through a membership process where they determined that this is what should be done, then it could happen," she said.

'Everybody around me was doing it'

Steroids are a controlled substance under federal law, but players who use them need not worry too much about prosecution. The DEA focuses on criminal operations, not individual users. When players are caught with steroids, it's often as part of a traffic stop or a local police investigation.

Jared Foster, 24, a quarterback recruited to play at the University of Mississippi, was kicked off the team in 2008 after local authorities arrested him for giving a man nandrolone, an anabolic steroid, according to court documents. Foster pleaded guilty and served jail time.

He told the AP that he doped in high school to impress college recruiters. He said he put on enough lean muscle to go from 185 pounds to 210 in about two months.

"Everybody around me was doing it," he said.

Steroids are not hard to find. A simple Internet search turns up countless online sources for performance-enhancing drugs, mostly from overseas companies.

College athletes freely post messages on steroid websites, seeking advice to beat tests and design the right schedule of administering steroids.

And steroids are still a mainstay in private, local gyms. Before the DEA shut down Alabama-based Applied Pharmacy Services as a major nationwide steroid supplier, sales records obtained by the AP show steroid shipments to bodybuilders, trainers and gym owners around the country.

Because users are rarely prosecuted, the demand is left in place after the distributor is gone.

When Joshua Hodnik was making and wholesaling illegal steroids, he had found a good retail salesman in a college quarterback named Vinnie Miroth. Miroth was playing at Saginaw Valley State, a Division II school in central Michigan, and was buying enough steroids for 25 people each month, Hodnik said.

"That's why I hired him," Hodnik said. "He bought large amounts and knew how to move it."

Miroth, who pleaded no contest in 2007 and admitted selling steroids, helped authorities build their case against Hodnik, according to court records. Now playing football in France, Miroth declined repeated AP requests for an interview.

Hodnik was released from prison this year and says he is out of the steroid business for good. He said there's no doubt that steroid use is widespread in college football.

"These guys don't start using performance-enhancing drugs when they hit the professional level," the Oklahoma City man said. "Obviously it starts well before that. And you can go back to some of the professional players who tested positive and compare their numbers to college and there is virtually no change."

Maneafaiga, the former Hawaii running back, said his steroids came from Mexico. A friend in California, who was a coach at a junior college, sent them through the mail. But Maneafaiga believes the consequences were nagging injuries. He found religion, quit the drugs and became the team's chaplain.

"God gave you everything you need," he said. "It gets in your mind. It will make you grow unnaturally. Eventually, you'll break down. It happened to me every time."

At the DEA, Rannazzisi said he has met with and conducted training for investigators and top officials in every professional sport. He's talked to Major League Baseball about the patterns his agents are seeing. He's discussed warning signs with the NFL.

He said he's offered similar training to the NCAA but never heard back. Wilfert said the NCAA staff has discussed it and hasn't decided what to do.

"We have very little communication with the NCAA or individual schools," Rannazzisi said. "They've got my card. What they've done with it? I don't know."

___

Associated Press writers Ryan Foley in Cedar Rapids, Iowa; David Brandt in Jackson, Miss.; David Skretta in Lawrence, Kan.; Don Thompson in Sacramento, Calif.;and Alexa Olesen in Shanghai, China; and researchers Susan James in New York and Monika Mathur in Washington contributed to this report.

___

Contact the Washington investigative team at DCinvestigations (at) ap.org.

Whether for athletics or age, Americans from teenagers to baby boomers are trying to get an edge by illegally using anabolic steroids and human growth hormone, despite well-documented risks. This is the first of a two-part series.

Source: http://news.yahoo.com/ap-impact-steroids-loom-major-college-football-080545936--spt.html

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Thursday, December 20, 2012

Foursquare Partnership May Give Apple a Route to Maps Success

MacNewsWorld writes, Apple is reportedly in talks with Foursquare about a data-sharing deal that would allow it to use Foursquare's local information to help further develop its mapping application. The Foursquare mobile app uses smartphone users' location to help them find nearby restaurants, bars or services. Users can also check in at locations and display the information on social networks like Facebook and Twitter, sometimes leading to special deals from the location.

Continue reading Foursquare Partnership May Give Apple a Route to Maps Success at MacNewsWorld

Source: http://machash.com/macnewsworld/47073/foursquare-partnership-may-give-apple-a-route-to-maps-success/

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Wednesday, December 19, 2012

A Look at State Gun Laws Across the Country, California Most Tough Regulations

December 17, 2012 Updated Dec 17, 2012 at 6:26 PM PST

The latest tragedy in Connecticut has once again sparked the debate over gun control.

Gun laws differ in each state. Some have tight rules, while others don't have many regulations.

California has some of the toughest laws in the country. Gun control advocates say they would like every state to get on that same page, but some say the rules are too strict.

It's an issue that's created heated debate for decades, and gun control is now front and center once again. Advocates for tighter laws say now is the time to act.

Robyn Thomas, Law Center to Prevent Gun Violence says, "It's just amazing that people don't realize that having weak gun laws just makes your life a heck of a lot more dangerous. It doesn't make you any safer."

Fresno gun store owner Barry Bauer says, "The trigger doesn't pull itself. Somebody has to pull the trigger."

Statewide gun laws across the country vary. Some states have strong regulations in place, while others are very lenient.

In Alaska, Arizona, Vermont and Wyoming, people are allowed to carry a concealed weapon without a permit. That law is even more lax in Vermont, where a person as young as 16 can legally buy and carry a handgun.

Thomas says, "The idea that you want to have 16-year-olds legally able to buy a gun and carry it loaded is just crazy to me. It's not even a legal argument, it's a sanity argument."

"I think that's fine, what difference does it make? Everybody in the United States has the right to have a firearm, the second amendment says so," says Bauer.

35 states also allow the open carry of handguns without a permit. In 20 states, there is no minimum age to buy a shotgun from an unlicensed dealer.

"Things are going along fine in those states. Every gun that we can't sell in California is being sold in virtually every other state in the union," says Bauer.

Barry Bauer runs a gun store in Fresno; in a state with some of the country's most aggressive gun laws.

"They're probably too much. We're over-regulated."

California began stepping up it's regulations about 20 years ago. Some of those include background checks on all gun purchases and a ban on assault weapons. Advocates say gun deaths have dropped about 40% because of these laws. They want to see others follow suit.

"We need help. We need some basic measures at the federal level and we need other states to step up," says Thomas.

Source: http://www.ksee24.com/news/local/Weapon-Laws---AGR-183864691.html

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Tuesday, December 18, 2012

Home for the Holidays: Dysfunctional Families ? Keyframe - Explore ...

Yours, mine, ours: Nuclear families explode in a variety of ways.

DOGTOOTH

A family functions by its own rules in 'Dogtooth.'

By Robert Ham

One of the biggest buzzwords of the holiday season is, of course, family. This is supposed to be the time when all of us fall into the embrace of our actual relatives or the friends that we have replaced our blood relations with. For many people, that?s an exciting notion that they look forward to with great anticipation. For others, it is a thought that is troubling or fraught with unwanted tension and uncomfortable emotion. It is for those people in the latter category that this list was put together. These are the films that feature family situations that will hopefully help assuage your concerns about heading home for the holidays; the types of movies that you can draw from as a reminder that, well, you have it better.

1. Dogtooth (2009, Yorgos Lanthimos)
Meet the ultimate dysfunctional family. This dark masterwork from Greece centers around three young people who have been isolated from the rest of the world by their strange, overprotective parents. They have been taught a weird vocabulary, think that airplanes flying overhead are toys that occasionally drop into their yard, and have never been beyond the walls of the small compound their parents own. When small slivers of the outside world find their way inside the family home, things quickly go from strange to discomfiting.

2. Ursula (1961, Lloyd Michael Williams)
Psychological dramas are rarely this disturbing and experimental, but mercifully this one is dispensed of in a tidy 11 minutes of warped imagery and action. The titular character is a young girl being crushed under the weight of her overbearing mother. How bad is it? When Ursula damages the dress she is wearing after falling out of a tree, her mother teaches her a lesson by killing her pet bird in front of her.

TIMES AND WIND

Two Turkish assert their independence in 'Times and Winds.'

3. Times and Winds (2006, Reha Erdem)
The young people in this beautiful Turkish film are, like any similar children their age across the globe, struggling to find their place in the world, and to assert their independence. For Omer, one of the three kids that the story centers on, it is a struggle to remove himself from under the thumb of his Muslim cleric father; for others, it is finding the first stirrings of sexual desire curtailed by your parents? intrusions.

4. Mutum (2007, Sandra Kogut)
The remote province of Minas Gerais is the setting for this searing and poignant film that sees the struggles of migrant farmers and a frayed family relationship through the eyes of a shy, quiet 10-year-old boy. This work is made even more poetic and real due to the fact that almost all the people in it are non-actors?many of whom had never seen a movie before?all improvising their dialogue.

5. The Last Homecoming (2008, Korinna Avraamidou)
Set just prior to the Turkish invasion of Cyprus, this Greek drama reflects the international tensions through the personal upheavals taking place within one family unit. Much of the stress emanates from romantic relationships, past and present, but is only the catalyst that helps ignite an already volatile situation between the three siblings in the film.

6. Home (2008, Ursula Meier)
The metaphor of industrialization, environmental degradation and humans? attempts to adapt to this quickly changing world is the key to unlocking this quietly moving drama. But it is of course viewed through the prism of one family that is forced to deal with a once-abandoned highway near its home that is suddenly put back into use. Once their quiet, relative solitude is upended, the fissures start to appear.

Source: http://www.fandor.com/blog/home-for-the-holidays-dysfunctional-families

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Monday, December 17, 2012

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Friday, December 7, 2012

Friday, Dec. 7 television and radio sports listings for Cleveland and Northeast Ohio

CLEVELAND, Ohio

Today's TV and radio sports listings?

COLLEGE FOOTBALL? ?

8 p.m. FCS playoffs, Sam Houston State vs. Montana State, ESPN2 ?

GOLF? ?

6:30 a.m. Nelson Mandela Championship, Golf Channel? ?

10:30 a.m. Dubai Ladies Masters (tape), Golf Channel? ?

1 p.m. Franklin Templeton Shootout, Golf Channel? ?

8 p.m. Australian Open, Golf Channel? ?

1 a.m. Thailand Championship, Golf Channel ?

HIGH SCHOOL BOYS BASKETBALL? ?

7 p.m. Lakeside vs. University, AM/970 ?

HOCKEY? ?

7 p.m. NCAA, Michigan State at Notre Dame, NBCSN? ?

7 p.m. AHL, LAKE ERIE MONSTERS at Charlotte, AM/850 ?

MENS COLLEGE BASKETBALL? ?

8 p.m. Iowa State at Iowa, Big Ten Network? ?

9:15 p.m. VCU at Old Dominion, NBCSN ?

MENS COLLEGE CUP SOCCER? ?

7:30 p.m. Indiana vs. Creighton, ESPNU ?

NBA? ?

7 p.m. Boston at Philadelphia, ESPN ? ?

8 p.m. CLEVELAND CAVALIERS at Minnesota, Fox Sports Ohio; AM/1100 ? ?

9:30 p.m. Los Angeles Lakers at Oklahoma City, ESPN ?

Source: http://www.cleveland.com/sports/index.ssf/2012/12/friday_dec_7_television_and_ra.html

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Thursday, December 6, 2012

Wednesday, December 5, 2012

Kruk to replace Francona in ESPN Sunday booth

By RONALD BLUM

AP Sports Writer

Associated Press Sports

updated 8:54 a.m. ET Dec. 3, 2012

NASHVILLE, Tenn. (AP) - John Kruk is following Bobby Valentine and Terry Francona into ESPN's Sunday night baseball booth.

Is he going to emulate them and wind up managing a major league team in 2014?

"I think that is why they are putting me in the booth," Kruk said before adding: "Ain't no chance of that happening."

A member of ESPN's studio team since 2004, the three-time All-Star will be announced Monday as the new partner of Dan Shulman and Orel Hershiser, giving ESPN a different trio for the third straight season after 21 consecutive years with Jon Miller and Joe Morgan. Buster Olney remains as the crew's reporter.

Shulman and Hershiser were in the Sunday night booth in 2011 along with Valentine, who left to become manager of the Red Sox and was replaced by Francona, Boston's manager from 2004-11. Francona departed ESPN in October to become Cleveland's manager.

Kruk has been working in the Bristol, Conn., studio about eight days a month and has filled in on game coverage. He expects his studio work to be roughly cut in half next season when he shifts to Sunday nights, ESPN's top baseball event because it has an exclusive window.

He never wanted to be a game analyst.

"I was always uncomfortable when former players came into your clubhouse, and I don't know why I felt that way," Kruk said.

He began to change his mind about game work when he accompanied Valentine's on ESPN's bus tour of spring training sites.

"I got more carte blanche ballparks than some of the other guys," he said Sunday. "I was in the training room, talking to players. Bobby Valentine took me to some parts I wasn't supposed to be in. Wish he'd told me when I had to get out."

Kruk then realized "you get more information when you're there than just sitting in the studio."

He hit .300 and had exactly 100 home runs during a big league career from 1986-95 with San Diego, Philadelphia and the Chicago White Sox. His most famous moment occurred during the 1993 All-Star game at Baltimore, when Randy Johnson's first pitch to him was a fastball that sailed way over Kruk's head.

Kruk pounded his heart in jest, flinched at a strike down the middle, flailed at two curveballs and then bowed to Johnson.

Part of the reason for his newfound comfort in the booth is that very few players remain from his time on the field.

"Unless Jamie Moyer comes back," Kruk said, laughing.

Actually, there are a few others, including Derek Jeter, Andy Pettitte and Mariano Rivera.

Kruk thought he may have been part of Rivera's first game for the Yankees. Actually, it was the fifth appearance for Rivera, a Fourth of July game when he pitched shutout ball for the first time - eight scoreless innings. Kruk took a called third strike and walked twice in Chicago's 4-1 loss.

? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Dominoes are set to fall

DeMarco: Baseball's annual winter meetings commence on Sunday, and eyes will be on prime prizes like Zack Greinke, who could command a record contract regardless of where he lands.

Source: http://nbcsports.msnbc.com/id/50056827/ns/sports-baseball/

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Tuesday, December 4, 2012

Family, Parenting, Reviews, and Giveaways - The Attic Girl ...

I have never been a huge fan of salty soft pretzels, but the guys in my family love them. ?My hubby often will buy a warm pretzel as a treat when we're out and about at the mall or running errands. ? ?But it can get expensive to buy them individually at snack stands. ?When he was at a football game just recently, they were asking $.50 just for a small container of cheese sauce to go with a $3.50 pretzel. ?Youch!

soft pretzels, snacksLuckily, there's an easy more wallet-friendly way to get that warm pretzel goodness right at home with SUPERPRETZEL. ?J and J Snack foods has made a delicious addition to their pretzel line: ?SuperPretzel Sweet Cinnamon.
snacks, soft pretzels
These come in a box of 6 so it easily feeds the four of us. Definitely a plus for a mom on a budget!

As I said, I don't usually eat pretzels. ?I don't like the saltiness of them. ?But when I heard that these had cinnamon, I figured I'd give them a try along with the guys.

These are really simple to prepare. ?Take them out of the freezer and either bake them in your toaster oven or regular oven at 400 for 5-6 minutes. ?(You can microwave them too but I prefer them baked because I like the outside crisper) ?You can moisten them with a little water or use a spray butter/margarine. ?Then sprinkle on the cinnamon included in the box. ? If you're making just a few pretzels and not the whole box, you can store your cinnamon in a ziplock bag. ? ? (The bag is a pretty good size)





I was pleasantly surprised at how good these taste! ?There's no salty flavor to them; they are sweet and remind me of a cinnamon bread stick. ?My hubby and son both loved them and ate 2 each. ?Hubby said he used to like to heat up pretzels fast in the microwave, but he likes the taste of them baked even more. ??I love how easy and quick they are to make!







soft pretzels, snackssnacks, soft pretzelsNot just for a snack or dessert, cinnamon pretzels will make a nummy breakfast or lunch choice too. ?You can eat them plain, topped with cinnamon sugar, dunk them in icing or chocolate sauce, or add to the side of some delicious ice cream. ?There are so many choices! ? I can't wait to experiment with different items to dip them in.





You can go to?http://wwww.superpretzel.com/sweetcinnamon/recipe.html for more fun recipe ideas.



SUPERPRETZEL Sweet Cinnamon pretzels are available in the frozen snacks section of your local retail store and supercenters. ?You can head on over to their website to find a store that carries them in your area as well as a money saving coupon?



Connect with SUPERPRETZEL:

Facebook: ?http://www.facebook.com/SUPERPRETZEL
Twitter: ? ?@jjsnackfoods
Blog: ? http://www.originalsuperpretzel.blogspot.com

Disclosure: ?I received two boxes of pretzels and coupons for review purposes. ?No other compensation was received and all opinions are my own. ?Your experience may differ from mine. ?For more info. see my full Disclosure Policy.

Source: http://www.atticgirl.com/2012/12/superpretzel-sweet-cinnamon-pretzels.html

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With military's push, biofuels can grow

US Senate voted Wednesday to restore the Defense Department's ability to buy biofuels. As the largest petroleum user in the world, the US military says its dependence on oil is a national security threat.

By Andrew Holland,?Contributor / December 2, 2012

An F-15E Strike Eagle receives fuel from a 100th Air Refueling Wing KC-135 Stratotanker during an aerial refuelling mission over the Atlantic Ocean in this September file photograph. The Department of Defense wants the option to buy biofuels in the event that its access to oil is threatened.

Ethan Morgan/US Air Force/Handout/Reuters/File

Enlarge

One of the most remarkable changes over the last five years has been the military's 'awakening' on?energy?issues. Before the Iraq War, the Pentagon just 'assumed'?energy?was always available when it war-gamed conflicts. But we now know that availability of?energy?? especially liquid fuels ? is critical for our ability to fight and win our wars.
?
The US Department of Defense is the largest user of petroleum in the world. In fiscal year 2011, it used 117 million barrels of oil ? almost 5 billion gallons of petroleum products in one year. This amounts to about 2 percent of the total usage of the country. This all came at a cost of $17.3 billion in 2011. This adds up to about 80 percent of the government's total?energy?consumption.
?
Napoleon used to say that an army marches on its stomach. Our military today fights based on a sea of oil. During World War II, our Army used about one gallon of fuel per day, per soldier. We now use an average of 20 gallons per day, per soldier when deployed in Afghanistan.

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For strategic and budgetary reasons, the military has identified this dependence on oil ? a single point of failure ? as a threat to national security. The Air Force and (especially) the Navy have embarked on a program to address this threat. Put together, the potential market for Air Force and Navy biofuels is expected to be about 700 million gallons per year by 2020. For an industry that is only just beginning to commercially produce fuel now, that will require significant investment. But it also should give investors some certainty that there will be a buyer for these fuels, so long as they are available. Once capital is made available for commercial-scale plants, this sector can grow very quickly.

On Wednesday, the Senate passed an amendment to the 2013 Defense Authorization bill that would restore the military's ability to buy biofuels. A previous amendment by Sen. James Inhofe (R) of Oklahoma, inserted earlier this year in the committee markup, would have prohibited biofuels purchases, unless they were cheaper than petroleum fuels. Sixty two senators voted in favor of the amendment, and restored the Department of Defense's ability to choose how it fuels and equips its forces.

The military has a long tradition of incubating and stimulating new industries, ranging from steel to the Internet, microchips to nuclear power. The advanced, drop-in biofuel industry could be the next industry that is stimulated by the military's vast buying power.

? This article is a modified version of a story in?Energy Trends Insider, a?free subscriber-only newsletter?that identifies and analyzes financial trends in the energy sector. It's?published by?Consumer Energy Report.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/qaCn4QtH8TI/With-military-s-push-biofuels-can-grow

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Thursday, November 29, 2012

Arizona declines to set up state-based health insurance exchange

PHOENIX (Reuters) - Arizona Governor Jan Brewer, an ardent critic of President Barack Obama's push to overhaul the U.S. healthcare system, said on Wednesday she was rejecting a new federal mandate to establish a state-based health insurance exchange under the U.S. Affordable Care Act.

Citing lingering unanswered questions about the exchanges and concerns about high costs she said would be passed on to Arizona families and small businesses, Brewer, a Republican, said her state would opt instead for a federally run exchange.

Such networks, designed to function as online insurance markets where consumers can shop for private coverage at federally subsidized rates, are an integral provision of the act, a centerpiece of Obama's first term in office.

(Reporting by David Schwartz; Writing by Steve Gorman; Editing by Cynthia Johnston)

Source: http://news.yahoo.com/arizona-declines-set-state-based-health-insurance-exchange-220349649.html

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Wednesday, November 28, 2012

Google adds detailed mapping to 45 Russian cities

Image

Were Yakov Smirnoff here, he'd probably try and crowbar in an "In Soviet Russia, cities Google you!" gag, but we're above such mischief. As such, we'll just let you know that Mountain View's Russian branch has added detailed mapping information for 45 new cities, including Vladivostok, Donetsk and Sochi, the home of the 2014 Winter Games. We'd suggest downloading the mapping data for the whole bunch while over your 3G connection and see if you don't win a prize, after all, it's happened before.

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Source: Google Russia (Translated)

Source: http://www.engadget.com/2012/11/27/google-maps-russia-45/

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Tuesday, November 27, 2012

Role Of SCUBA Diving Gear In Technical And Recreational Diving ...

If you had to ditch your gear would you be able to remove your BCD on your own? The bubbles that can be seen falling towards the divers? feet because are actually really rising to the surface. Scuba divers dive in shark cages and in most cases diving equipment rental tends to be cheaper than they would if you were not using a cage. For the past 25 years, the island of Phuket has catered for a large number of tourists from all over the world, a large percentage of whom are scuba divers looking to dive on some Asia?s finest dive sites. Orcas Island, the largest island off the coast of Washington state, is often called as ?gem of the San Juan islands?.

Look for a simple scuba workout combined with nearly any form of cardio to help you move into the ?fat but fit? category. It is not uncommon for a shark?s pectoral fin to glide just into the gap in the cage as it swims past. Louis club frequently gives back to its community in special ways. Keen surfers who are holidaying on the east coast should head over to Arugam Bay, widely renowned as one of the best surf spots in Sri Lanka. This means that the decision between renting your scuba gear and purchasing your scuba gear is even more critical if you?re above average in size.

If you don?t have a set of weights and a workout bench, get one. Even if you aren?t a diver, glass bottomed boat tours are offered here, and the beach is also noted as having some of the most active night life on the island. Therefore, you should also follow proper procedures before you take you nude diving adventure. Oxygen tanks and the tubes and mouthpieces which allow the user to inhale and exhale air from them are very common these days. This zero gravity environment provides the backdrop for romance, intrigue and adventure.

We often have rebreather divers joining us for some leisure diving or rebreather training in Kota Kinabalu, Sabah, Borneo and one of the questions we often get asked by recreational divers is ?How does a rebreather work??. Why Altitude Corrections for scuba diving? If you are already qualified either with BSAC or another recognised dive agency and looking to join a club, or returning after a break from the sport, then the club will be happy to welcome you with a discounted joining fee. The schools offer training to the individuals followed by the certificates. Artificial reefs are fantastic underwater attractions for divers and they also provide new habitats for underwater species.

They just made it an official PADI basic open water certification along with a membership to the club. In this case it would be best not to fret too much about your weight initially, instead concentrate on improving your overall fitness as it will have a much larger impact on your ability to scuba dive. Children and adults can learn about the ocean and all the animals found in it, up close and personal. Many divers risk their lives by overlooking certain risks. The oceans are full of things that humans can use to help with real life situations.

For deeper dives the Air Diluent would swapped out for different mixtures of Trimix (Helium, Nitrogen and Oxygen). The first requirement is the divers must be 10 years old to enroll in a diving course. If the outside pressure is 30 and inside pressure is 10, then eardrum will bulge inside, until the inside pressure is 30. One thing all of these events had in common is they were organized and planned especially for members in the pursuit of fun. In addition to the great feeling that you get while diving nude, there are also the safety considerations.

You have to remain calm while your face is being submerged in water, which can cause a natural reflex of feeling like you are going to drown. It is one of the most beautiful places on earth and only a few fortunate people take time to see the beauty that it has to offer. Cuba has the second largest barrier reef system in the world which sits in clear warm waters. Scuba diving is not only a fun activity for all but it can be useful in the field of marine biology. Dives of different depths are planned depending upon the experience of the divers.

You have to use more air than when you are younger and carrying the heavy equipment can be a bit of a problem. Cardiovascular fitness should be the area to focus your efforts as this will have the greatest effect on air consumption and general comfort while scuba diving. On 20th November, 1619, a hurricane hit the Caribbean island and the moorings gave way sending it crashing into the surrounding reefs and rocks. Travellers flock to the Indian Ocean destination for its warm turquoise crystal clear waters, pristine white sand and palm-infringed beaches, and luxury Maldives hotels comprising beach resorts and luxury water villas on stilts above the calm sparkling ocean waters. The area is well known for its beautiful colourful coral reefs and hundreds of species of tropical fish.

That?s not bad of an investment for the end results. If you feel that you are fit, even though you are considered to be overweight, then it is most likely that you will have little difficulty scuba diving, with the exception of possible equipment issues related to your size. It involves working of all muscle groups thus providing a complete cardiovascular exercise. ?In all of Ecuador there were 1,489 diver certifications issued in 2011. To organise a refresher course or a free taster session email or call the centre on 07951 855725 or trydives@bracknellscuba.org.uk.

We did most of our training in the locks at the submarine base. Dives of different depths are planned depending upon the experience of the divers.
scuba

Source: http://freebookfor.com/2012/11/24/role-of-scuba-diving-gear-in-technical-and-recreational-diving/

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Source: http://stantonmarsh88.typepad.com/blog/2012/11/role-of-scuba-diving-gear-in-technical-and-recreational-diving.html

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Friday, November 23, 2012

Protein folding: Look back on scientific advances made as result of 50-year old puzzle

ScienceDaily (Nov. 22, 2012) ? Fifty years after scientists first posed a question about protein folding, the search for answers has led to the creation of a full-fledged field of research that led to major advances in supercomputers, new materials and drug discovery, and shaped our understanding of the basic processes of life, including so-called "protein-folding diseases" such as Alzheimer's, Parkinson's and type II diabetes.

In an article in Science, Stony Brook University researchers reviewed the progress on a 50-year-old puzzle called the Protein Folding Problem. Ken Dill and Justin MacCallum of Stony Brook's Louis and Beatrice Laufer Center for Physical and Quantitative Biology show how a community of scientific researchers rose to tackle a grand-challenge problem of very basic science that had no obvious payoff at the time.

"Protein folding is a quintessential basic science. There has been no specific commercial target, yet the collateral payoffs have been broad and deep," the researchers said in their paper, The Protein Folding Problem, 50 Years On.

"We have learned that proteins fold rapidly because random thermal motions cause conformational changes leading energetically downhill toward the native structure, a principle that is captured in funnel-shaped energy landscapes. And thanks in part to the large Protein Data Bank of known structures, predicting protein structures is now far more successful than was thought possible in the early days. What began as three questions of basic science one half-century ago has now grown into the full-fledged research field of protein physical science."

This year marks the 50th anniversary of the 1962 Nobel Prize in Chemistry awarded to Max Perutz and John Kendrew for their pioneering work in determining the structure of globular proteins. That work laid the foundation for structural biology, which interprets molecular level biological mechanisms in terms of the structures of proteins and other biomolecules. Their work also raised the question of how protein structures are explained by physical principles.

Since Perutz and Kendrew discovered the structures of two proteins, nearly 80,000 protein structures have been discovered. The protein folding "problem" arose when Perutz and Kendrew were unable to make sense of how the folded structure of the protein molecule was related to its sequence of bead types. Ever since then, there has been great interest in understanding the protein-folding "code": how does a given string of amino acids lead to a particular balled-up ("native") structure of a protein?

Proteins are molecules that perform the basic functions in biological cells -- converting food to growth, to repairing DNA molecules and damaged cell parts, to motion in muscles, to transduction of signals in the brain and light in the eye, for example. Humans have about 20,000 different types of protein molecules. Each performs a different function. The abilities of proteins to perform such a broad array of powerful chemical functions arise from a peculiar principle of chemical structure and function, namely the folding of each protein. A protein is miniature string of beads, like a pearl necklace, where the bead-like component pieces are called amino acids. Amino acids come in 20 different types. The folding principle is that different sequences of amino acids strung together cause different protein molecules to ball-up in very specific, but different, ways, giving rise to their very different functionalities.

The protein folding problem became a set of three inter-related puzzles: What is the folding code? How does the protein find its one native structure in fractions of a second inside the cell (the needle-in-a-haystack problem)? And: Can we make a computer method that can discover new structures of proteins from the large number of amino acid sequences that are now known?

Dill, Director of the Laufer Center and Distinguished Professor of Physics and Chemistry, and MacCallum, a junior fellow at the Laufer Center, describe how huge advances have been made on all three fronts. They detail some very important collateral payoffs of this work that was completely unanticipated at the time, including the development of the IBM Blue Gene computer and distributed-grid computing, computer-based methods for discovering new pharmaceuticals, a deeper understanding of molecular mechanisms in biology, a deeper understanding of the inter-atomic interactions inside proteins (that has also involved Stony Brook Laufer Center researchers Carlos Simmerling, David Green, and Rob Rizzo), and a new class of very promising polymer materials called "foldamers."

Dill and MacCallum argue that what started out as one compelling question of basic science has now become an entire field of theoretical and experimental approaches in which many questions are now leading to a few answers and many more questions.

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The above story is reprinted from materials provided by Stony Brook University.

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Journal Reference:

  1. K. A. Dill, J. L. MacCallum. The Protein-Folding Problem, 50 Years On. Science, 2012; 338 (6110): 1042 DOI: 10.1126/science.1219021

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/-AO1KPe6jy8/121122152910.htm

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ScienceDaily: Gene News

ScienceDaily: Gene Newshttp://www.sciencedaily.com/news/health_medicine/genes/ Genes and Genetics News. Read today's medical research in genetics including what can damage genes, what can protect them, and more.en-usThu, 22 Nov 2012 17:24:20 ESTThu, 22 Nov 2012 17:24:20 EST60ScienceDaily: Gene Newshttp://www.sciencedaily.com/images/logosmall.gifhttp://www.sciencedaily.com/news/health_medicine/genes/ For more science articles, visit ScienceDaily.Scientists describe elusive replication machinery of flu viruseshttp://www.sciencedaily.com/releases/2012/11/121122152928.htm Scientists have made a major advance in understanding how flu viruses replicate within infected cells. The researchers used cutting-edge molecular biology and electron-microscopy techniques to ?see? one of influenza?s essential protein complexes in unprecedented detail. The images generated in the study show flu virus proteins in the act of self-replication, highlighting the virus?s vulnerabilities that are sure to be of interest to drug developers.Thu, 22 Nov 2012 15:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121122152928.htmProtein folding: Look back on scientific advances made as result of 50-year old puzzlehttp://www.sciencedaily.com/releases/2012/11/121122152910.htm Fifty years after scientists first posed a question about protein folding, the search for answers has led to the creation of a full-fledged field of research that led to major advances in supercomputers, new materials and drug discovery, and shaped our understanding of the basic processes of life, including so-called "protein-folding diseases" such as Alzheimer's, Parkinson's and type II diabetes.Thu, 22 Nov 2012 15:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121122152910.htmStep forward in regenerating and repairing damaged nerve cellshttp://www.sciencedaily.com/releases/2012/11/121121145638.htm Researchers recently uncovered a nerve cell's internal clock, used during embryonic development. This breakthrough could lead to the development of new tools to repair and regenerate nerve cells following injuries to the central nervous system.Wed, 21 Nov 2012 14:56:56 ESThttp://www.sciencedaily.com/releases/2012/11/121121145638.htmArchitecture of rod sensory cilium disrupted by mutationhttp://www.sciencedaily.com/releases/2012/11/121121145621.htm Using a new technique called cryo-electron tomography, scientists have created a three-dimensional map that gives a better understanding of how the architecture of the rod sensory cilium (part of one type of photoreceptor in the eye) is changed by genetic mutation and how that affects its ability to transport proteins as part of the light-sensing process.Wed, 21 Nov 2012 14:56:56 ESThttp://www.sciencedaily.com/releases/2012/11/121121145621.htmAging: Scientists further unravel telomere biologyhttp://www.sciencedaily.com/releases/2012/11/121121130933.htm Researchers have resolved the structure of that allows a telomere-related protein, Cdc13, to form dimers in yeast. Mutations in this region of Cdc13 put the kibosh on the ability of telomerase and other proteins to maintain telomeres.Wed, 21 Nov 2012 13:09:09 ESThttp://www.sciencedaily.com/releases/2012/11/121121130933.htmNovel mechanism through which normal stromal cells become cancer-promoting stromal cells identifiedhttp://www.sciencedaily.com/releases/2012/11/121121104401.htm New understanding of molecular changes that convert harmless cells surrounding ovarian cancer cells into cells that promote tumor growth and metastasis provides potential new therapeutic targets for this deadly disease, according to new research.Wed, 21 Nov 2012 10:44:44 ESThttp://www.sciencedaily.com/releases/2012/11/121121104401.htmEvolution of human intellect: Human-specific regulation of neuronal geneshttp://www.sciencedaily.com/releases/2012/11/121120194926.htm A new study has identified hundreds of small regions of the genome that appear to be uniquely regulated in human neurons. These regulatory differences distinguish us from other primates, including monkeys and apes, and as neurons are at the core of our unique cognitive abilities, these features may ultimately hold the key to our intellectual prowess (and also to our potential vulnerability to a wide range of 'human-specific' diseases from autism to Alzheimer's).Tue, 20 Nov 2012 19:49:49 ESThttp://www.sciencedaily.com/releases/2012/11/121120194926.htmRibosome regulates viral protein synthesis, revealing potential therapeutic targethttp://www.sciencedaily.com/releases/2012/11/121120132906.htm Rather than target RNA viruses directly, aiming at the host cells they invade could hold promise, but any such strategy would have to be harmless to the host. Now, a surprising discovery made in ribosomes may point the way to fighting fatal viral infections such as rabies.Tue, 20 Nov 2012 13:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121120132906.htmHow does antibiotic resistance spread? Scientists find answers in the nosehttp://www.sciencedaily.com/releases/2012/11/121120121835.htm Microbiologists studying bacterial colonization in mice have discovered how the very rapid and efficient spread of antibiotic resistance works in the respiratory pathogen, Streptococcus pneumoniae (also known as the pneumococcus). The team found that resistance stems from the transfer of DNA between bacterial strains in biofilms in the nasopharynx, the area just behind the nose.Tue, 20 Nov 2012 12:18:18 ESThttp://www.sciencedaily.com/releases/2012/11/121120121835.htmScientists identify inhibitor of myelin formation in central nervous systemhttp://www.sciencedaily.com/releases/2012/11/121120100155.htm Scientists have discovered another molecule that plays an important role in regulating myelin formation in the central nervous system. Myelin promotes the conduction of nerve cell impulses by forming a sheath around their projections, the so-called axons, at specific locations -- acting like the plastic insulation around a power cord.Tue, 20 Nov 2012 10:01:01 ESThttp://www.sciencedaily.com/releases/2012/11/121120100155.htmTelomere lengths predict life expectancy in the wild, research showshttp://www.sciencedaily.com/releases/2012/11/121119213144.htm Researchers have found that biological age and life expectancy can be predicted by measuring an individual's DNA. They studied the length of chromosome caps -- known as telomeres -- in a 320-strong wild population of Seychelles Warblers on a small isolated island.Mon, 19 Nov 2012 21:31:31 ESThttp://www.sciencedaily.com/releases/2012/11/121119213144.htmCancer: Some cells don't know when to stophttp://www.sciencedaily.com/releases/2012/11/121119171403.htm Certain mutated cells keep trying to replicate their DNA -- with disastrous results -- even after medications rob them of the raw materials to do so, according to new research.Mon, 19 Nov 2012 17:14:14 ESThttp://www.sciencedaily.com/releases/2012/11/121119171403.htmMultiple sclerosis ?immune exchange? between brain and blood is uncoveredhttp://www.sciencedaily.com/releases/2012/11/121119163301.htm DNA sequences obtained from a handful of patients with multiple sclerosis have revealed the existence of an ?immune exchange? that allows the disease-causing cells to move in and out of the brain.Mon, 19 Nov 2012 16:33:33 ESThttp://www.sciencedaily.com/releases/2012/11/121119163301.htm3-D light switch for the brain: Device may help treat Parkinson's, epilepsy; aid understanding of consciousnesshttp://www.sciencedaily.com/releases/2012/11/121119114249.htm A new tool for neuroscientists delivers a thousand pinpricks of light to individual neurons in the brain. The new 3-D "light switch", created by biologists and engineers, could one day be used as a neural prosthesis that could treat conditions such as Parkinson's and epilepsy by using gene therapy to turn individual brain cells on and off with light.Mon, 19 Nov 2012 11:42:42 ESThttp://www.sciencedaily.com/releases/2012/11/121119114249.htmBlood cancer gene BCL6 identified as a key factor for differentiation of nerve cells of cerebral cortexhttp://www.sciencedaily.com/releases/2012/11/121119093848.htm The cerebral cortex is the most complex structure in our brain and the seat of consciousness, emotion, motor control and language. In order to fulfill these functions, it is composed of a diverse array of nerve cells, called cortical neurons, which are affected by many neurological and neuropsychiatric diseases. Researchers have opened new perspectives on brain development and stem cell neurobiology by discovering a gene called BCL6 as a key factor in the generation of cortical neurons during embryonic brain development.Mon, 19 Nov 2012 09:38:38 ESThttp://www.sciencedaily.com/releases/2012/11/121119093848.htmMinority report: Insight into subtle genomic differences among our own cellshttp://www.sciencedaily.com/releases/2012/11/121118141530.htm Scientists have demonstrated that induced pluripotent stem cells -- the embryonic-stem-cell look-alikes whose discovery a few years ago won this year's Nobel Prize in medicine -- are not as genetically unstable as was thought.Sun, 18 Nov 2012 14:15:15 ESThttp://www.sciencedaily.com/releases/2012/11/121118141530.htmSkin cells reveal DNA's genetic mosaichttp://www.sciencedaily.com/releases/2012/11/121118141524.htm The prevailing wisdom has been that every cell in the body contains identical DNA. However, a new study of stem cells derived from the skin has found that genetic variations are widespread in the body's tissues, a finding with profound implications for genetic screening.Sun, 18 Nov 2012 14:15:15 ESThttp://www.sciencedaily.com/releases/2012/11/121118141524.htmLikely basis of birth defect causing premature skull closure in infants identifiedhttp://www.sciencedaily.com/releases/2012/11/121118141432.htm Geneticists, pediatricians, surgeons and epidemiologists have identified two areas of the human genome associated with the most common form of non-syndromic craniosynostosis premature closure of the bony plates of the skull.Sun, 18 Nov 2012 14:14:14 ESThttp://www.sciencedaily.com/releases/2012/11/121118141432.htmDNA packaging discovery reveals principles by which CRC mutations may cause cancerhttp://www.sciencedaily.com/releases/2012/11/121117184658.htm A new discovery concerning a fundamental understanding about how DNA works will produce a "180-degree change in focus" for researchers who study how gene packaging regulates gene activity, including genes that cause cancer and other diseases.Sat, 17 Nov 2012 18:46:46 ESThttp://www.sciencedaily.com/releases/2012/11/121117184658.htmHepatitis C treatment's side effects can now be studied in the labhttp://www.sciencedaily.com/releases/2012/11/121116161059.htm Adverse side effects of certain hepatitis C medications can now be replicated in the lab, thanks to a research team. The new method aids understanding of recent failures of hepatitis C antiviral drugs in some patients, and could help to identify medications that eliminate adverse effects. The findings may aid the development of safer and more effective treatments for hepatitis C and other pathogens such as SARS and West Nile virus.Fri, 16 Nov 2012 16:10:10 ESThttp://www.sciencedaily.com/releases/2012/11/121116161059.htmReconsidering cancer's bad guyhttp://www.sciencedaily.com/releases/2012/11/121116124644.htm Researchers have found that a protein, known for causing cancer cells to spread around the body, is also one of the molecules that trigger repair processes in the brain.Fri, 16 Nov 2012 12:46:46 ESThttp://www.sciencedaily.com/releases/2012/11/121116124644.htmGene distinguishes early birds from night owls and helps predict time of deathhttp://www.sciencedaily.com/releases/2012/11/121116124551.htm New research shows that a gene is responsible for a person's tendency to be an early riser or night owl -- and helps determine the time of day a person is most likely to die.Fri, 16 Nov 2012 12:45:45 ESThttp://www.sciencedaily.com/releases/2012/11/121116124551.htmClues to cause of kids' brain tumorshttp://www.sciencedaily.com/releases/2012/11/121116091226.htm Insights from a genetic condition that causes brain cancer are helping scientists better understand the most common type of brain tumor in children.Fri, 16 Nov 2012 09:12:12 ESThttp://www.sciencedaily.com/releases/2012/11/121116091226.htmArthritis study reveals why gender bias is all in the geneshttp://www.sciencedaily.com/releases/2012/11/121115210541.htm Researchers have pieced together new genetic clues to the arthritis puzzle in a study that brings potential treatments closer to reality and could also provide insights into why more women than men succumb to the disabling condition.Thu, 15 Nov 2012 21:05:05 ESThttp://www.sciencedaily.com/releases/2012/11/121115210541.htmClass of RNA molecules protects germ cells from damagehttp://www.sciencedaily.com/releases/2012/11/121115172255.htm Passing one's genes on to the next generation is a mark of evolutionary success. So it makes sense that the body would work to ensure that the genes the next generation inherits are exact replicas of the originals. Biologists have now identified one way the body does exactly that.Thu, 15 Nov 2012 17:22:22 ESThttp://www.sciencedaily.com/releases/2012/11/121115172255.htmQuick test speeds search for Alzheimer's drugs: Compound restores motor function and longevity to fruit flieshttp://www.sciencedaily.com/releases/2012/11/121115152655.htm Researchers report that an efficient, high-volume technique for testing potential drug treatments for Alzheimer's disease uncovered an organic compound that restored motor function and longevity to fruit flies with the disease.Thu, 15 Nov 2012 15:26:26 ESThttp://www.sciencedaily.com/releases/2012/11/121115152655.htmProtein-making machinery can switch gears with a small structural change process; Implications for immunity and cancer therapyhttp://www.sciencedaily.com/releases/2012/11/121115133414.htm For the past several years, research has focused on the intricate actions of an ancient family of catalytic enzymes that play a key role in translation, the process of producing proteins. In a new study, scientists have shown that this enzyme can actually also work in another fundamental process in humans.Thu, 15 Nov 2012 13:34:34 ESThttp://www.sciencedaily.com/releases/2012/11/121115133414.htmPlant derivative, tanshinones, protects against sepsis, study suggestshttp://www.sciencedaily.com/releases/2012/11/121115133312.htm Researchers have discovered that tanshinones, which come from the plant Danshen and are highly valued in Chinese traditional medicine, protect against the life-threatening condition sepsis.Thu, 15 Nov 2012 13:33:33 ESThttp://www.sciencedaily.com/releases/2012/11/121115133312.htmStructure of enzyme topoisomerase II alpha unravelled providing basis for more accurate design of chemotherapeutic drugshttp://www.sciencedaily.com/releases/2012/11/121115132903.htm Medical researchers have for the first time described the structure of the active site core of topoisomerase II alpha, an important target for anti-cancer drugs. The type II topoisomerases are important enzymes that are involved in maintaining the structure of DNA and chromosome segregation during both replication and transcription of DNA. One of these enzymes, topoisomerase II alpha, is involved in the replication of DNA and cell proliferation, and is highly expressed in rapidly dividing cancer cells.Thu, 15 Nov 2012 13:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121115132903.htmNewly discovered enzyme important in the spreading of cancerhttp://www.sciencedaily.com/releases/2012/11/121115132901.htm Enzyme hunters at UiO have discovered the function of an enzyme that is important in the spreading of cancer. Cancer researchers now hope to inhibit the enzyme.Thu, 15 Nov 2012 13:29:29 ESThttp://www.sciencedaily.com/releases/2012/11/121115132901.htmGenetics point to serious pregnancy complication, pre-eclampsiahttp://www.sciencedaily.com/releases/2012/11/121115132613.htm New research has revealed a genetic link in pregnant moms - and their male partners - to pre-eclampsia, a life-threatening complication during pregnancy.Thu, 15 Nov 2012 13:26:26 ESThttp://www.sciencedaily.com/releases/2012/11/121115132613.htmMolecular mechanisms underlying stem cell reprogramming decodedhttp://www.sciencedaily.com/releases/2012/11/121115132344.htm Thanks to some careful detective work, scientist better understand just how iPS cells form ? and why the Yamanaka process is inefficient, an important step to work out for regenerative medicine. The findings uncover cellular impediments to iPS cell development that, if overcome, could dramatically improve the efficiency and speed of iPS cell generation.Thu, 15 Nov 2012 13:23:23 ESThttp://www.sciencedaily.com/releases/2012/11/121115132344.htmSurprising genetic link between kidney defects and neurodevelopmental disorders in kidshttp://www.sciencedaily.com/releases/2012/11/121115132342.htm About 10 percent of kids born with kidney defects have large alterations in their genomes known to be linked with neurodevelopmental delay and mental illness, a new study has shown.Thu, 15 Nov 2012 13:23:23 ESThttp://www.sciencedaily.com/releases/2012/11/121115132342.htmEven moderate drinking in pregnancy can affect a child's IQhttp://www.sciencedaily.com/releases/2012/11/121114172833.htm Relatively small levels of exposure to alcohol while in the womb can influence a child's IQ, according to a new study using data from over 4,000 mothers and their children.Wed, 14 Nov 2012 17:28:28 ESThttp://www.sciencedaily.com/releases/2012/11/121114172833.htmGene nearly triples risk of Alzheimer's, international research team findshttp://www.sciencedaily.com/releases/2012/11/121114171710.htm A gene so powerful it nearly triples the risk of Alzheimer's disease has been discovered by an international team of researchers. It is the most potent genetic risk factor for Alzheimer's identified in the past 20 years.Wed, 14 Nov 2012 17:17:17 ESThttp://www.sciencedaily.com/releases/2012/11/121114171710.htmDiscovery could lead to faster diagnosis for some chronic fatigue syndrome caseshttp://www.sciencedaily.com/releases/2012/11/121114171708.htm For the first time, researchers have landed on a potential diagnostic method to identify at least a subset of patients with chronic fatigue syndrome - testing for antibodies linked to latent Epstein-Barr virus reactivation.Wed, 14 Nov 2012 17:17:17 ESThttp://www.sciencedaily.com/releases/2012/11/121114171708.htmResearch breakthrough could halt melanoma metastasis, study suggestshttp://www.sciencedaily.com/releases/2012/11/121114153227.htm In laboratory experiments, scientists have eliminated metastasis, the spread of cancer from the original tumor to other parts of the body, in melanoma by inhibiting a protein known as melanoma differentiation associated gene-9 (mda-9)/syntenin.Wed, 14 Nov 2012 15:32:32 ESThttp://www.sciencedaily.com/releases/2012/11/121114153227.htmPig genomes provide massive amount of genomic data for human healthhttp://www.sciencedaily.com/releases/2012/11/121114134512.htm Researchers provide a whole-genome sequence and analysis of number of pig breeds, including a miniature pig that serves a model for human medical studies and therapeutic drug testing.Wed, 14 Nov 2012 13:45:45 ESThttp://www.sciencedaily.com/releases/2012/11/121114134512.htmRare parasitic fungi could have anti-flammatory benefitshttp://www.sciencedaily.com/releases/2012/11/121114134054.htm Caterpillar fungi are rare parasites found on hibernating caterpillars in the mountains of Tibet. For centuries they have been highly prized as a traditional Chinese medicine - just a small amount can fetch hundreds of dollars.Wed, 14 Nov 2012 13:40:40 ESThttp://www.sciencedaily.com/releases/2012/11/121114134054.htmCancer therapy: Nanokey opens tumors to attackhttp://www.sciencedaily.com/releases/2012/11/121114113803.htm There are plenty of effective anticancer agents around. The problem is that, very often, they cannot gain access to all the cells in solid tumors. A new gene delivery vehicle may provide a way of making tracks to the heart of the target.Wed, 14 Nov 2012 11:38:38 ESThttp://www.sciencedaily.com/releases/2012/11/121114113803.htmHigh sperm DNA damage a leading cause of 'unexplained infertility', research findshttp://www.sciencedaily.com/releases/2012/11/121114113235.htm New research has uncovered the cause of infertility for 80 per cent of couples previously diagnosed with 'unexplained infertility': high sperm DNA damage.Wed, 14 Nov 2012 11:32:32 ESThttp://www.sciencedaily.com/releases/2012/11/121114113235.htmA risk gene for cannabis psychosishttp://www.sciencedaily.com/releases/2012/11/121114083928.htm The ability of cannabis to produce psychosis has long been an important public health concern. This concern is growing in importance as there is emerging data that cannabis exposure during adolescence may increase the risk of developing schizophrenia, a serious psychotic disorder. Further, with the advent of medical marijuana, a new group of people with uncertain psychosis risk may be exposed to cannabis.Wed, 14 Nov 2012 08:39:39 ESThttp://www.sciencedaily.com/releases/2012/11/121114083928.htmBacterial DNA sequence used to map an infection outbreakhttp://www.sciencedaily.com/releases/2012/11/121113214635.htm For the first time, researchers have used DNA sequencing to help bring an infectious disease outbreak in a hospital to a close. Researchers used advanced DNA sequencing technologies to confirm the presence of an ongoing outbreak of methicillin-resistant Staphylococcus aureus (MRSA) in a Special Care Baby Unit in real time. This assisted in stopping the outbreak earlier, saving possible harm to patients. This approach is much more accurate than current methods used to detect hospital outbreaks.Tue, 13 Nov 2012 21:46:46 ESThttp://www.sciencedaily.com/releases/2012/11/121113214635.htmGenetic variation may modify associations between low vitamin D levels and adverse health outcomeshttp://www.sciencedaily.com/releases/2012/11/121113161506.htm Findings from a study suggest that certain variations in vitamin D metabolism genes may modify the association of low serum 25-hydroxyvitamin D concentrations with health outcomes such as hip fracture, heart attack, cancer, and death.Tue, 13 Nov 2012 16:15:15 ESThttp://www.sciencedaily.com/releases/2012/11/121113161506.htmNew type of bacterial protection found within cells: Novel immune system response to infections discoveredhttp://www.sciencedaily.com/releases/2012/11/121113143656.htm Biologists have discovered that fats within cells store a class of proteins with potent antibacterial activity, revealing a previously unknown type of immune system response that targets and kills bacterial infections.Tue, 13 Nov 2012 14:36:36 ESThttp://www.sciencedaily.com/releases/2012/11/121113143656.htmGlutamate neurotransmission system may be involved with depression riskhttp://www.sciencedaily.com/releases/2012/11/121113134807.htm Researchers using a new approach to identifying genes associated with depression have found that variants in a group of genes involved in transmission of signals by the neurotransmitter glutamate appear to increase the risk of depression.Tue, 13 Nov 2012 13:48:48 ESThttp://www.sciencedaily.com/releases/2012/11/121113134807.htmTargeting downstream proteins in cancer-causing pathway shows promise in cell, animal modelhttp://www.sciencedaily.com/releases/2012/11/121113134230.htm The cancer-causing form of the gene Myc alters the metabolism of mitochondria, the cell?s powerhouse, making it dependent on the amino acid glutamine for survival. Depriving cells of glutamine selectively induces programmed cell death in cells overexpressing mutant Myc. Using Myc-active neuroblastoma cells, a team three priotein executors of the glutamine-starved cell, representing a downstream target at which to aim drugs. Roughly 25 percent of all neuroblastoma cases are associated with Myc-active cells.Tue, 13 Nov 2012 13:42:42 ESThttp://www.sciencedaily.com/releases/2012/11/121113134230.htmEven low-level radioactivity is damaging, scientists concludehttp://www.sciencedaily.com/releases/2012/11/121113134224.htm Even the very lowest levels of radiation are harmful to life, scientists have concluded, reporting the results of a wide-ranging analysis of 46 peer-reviewed studies published over the past 40 years. Variation in low-level, natural background radiation was found to have small, but highly statistically significant, negative effects on DNA as well as several measures of health.Tue, 13 Nov 2012 13:42:42 ESThttp://www.sciencedaily.com/releases/2012/11/121113134224.htmLoss of essential blood cell gene leads to anemiahttp://www.sciencedaily.com/releases/2012/11/121113122220.htm Scientists have discovered a new gene that regulates heme synthesis in red blood cell formation. Heme is the deep-red, iron-containing component of hemoglobin, the protein in red blood cells responsible for transporting oxygen in the blood. The findings promise to advance the biomedical community's understanding and treatment of human anemias and mitochondrial diseases, both known and unknown.Tue, 13 Nov 2012 12:22:22 ESThttp://www.sciencedaily.com/releases/2012/11/121113122220.htmWatching the developing brain, scientists glean clues on neurological disorderhttp://www.sciencedaily.com/releases/2012/11/121113122133.htm Researchers have tracked a gene's crucial role in orchestrating the placement of neurons in the developing brain. Their findings help unravel some of the mysteries of Joubert syndrome and other neurological disorders.Tue, 13 Nov 2012 12:21:21 ESThttp://www.sciencedaily.com/releases/2012/11/121113122133.htmSolving the mystery of aging: Longevity gene makes Hydra immortal and humans grow olderhttp://www.sciencedaily.com/releases/2012/11/121113091953.htm Why do we get older? When do we die and why? Is there a life without aging? For centuries, science has been fascinated by these questions. Now researchers have examined why the polyp Hydra is immortal -- and unexpectedly discovered a link to aging in humans.Tue, 13 Nov 2012 09:19:19 ESThttp://www.sciencedaily.com/releases/2012/11/121113091953.htmMen and women battle for ideal height: Evidence of an intralocus sexual conflict currently raging in human DNAhttp://www.sciencedaily.com/releases/2012/11/121113083536.htm A battle about the ideal height would appear to be raging in men's and women's genes. A researcher in Sweden has shown that this conflict is leading to a difference in reproductive success between men and women of varying height.Tue, 13 Nov 2012 08:35:35 ESThttp://www.sciencedaily.com/releases/2012/11/121113083536.htmCatch and release of rare cancer cells inspired by jellyfishhttp://www.sciencedaily.com/releases/2012/11/121112171314.htm A research team has developed a novel device that may one day have broad therapeutic and diagnostic uses in the detection and capture of rare cell types, such as cancer cells, fetal cells, viruses and bacteria.Mon, 12 Nov 2012 17:13:13 ESThttp://www.sciencedaily.com/releases/2012/11/121112171314.htmJellyfish-inspired device that captures cancer cells from blood samples could enable better patient monitoringhttp://www.sciencedaily.com/releases/2012/11/121112171312.htm Tumor cells circulating in a patient's bloodstream can yield a great deal of information on how a tumor is responding to treatment and what drugs might be more effective against it. But first, these rare cells have to be captured and isolated from the many other cells found in a blood sample. Scientists are now working on microfluidic devices that can isolate circulating tumor cells.Mon, 12 Nov 2012 17:13:13 ESThttp://www.sciencedaily.com/releases/2012/11/121112171312.htmNew cause of thyroid hormone deficiency discoveredhttp://www.sciencedaily.com/releases/2012/11/121112135615.htm Researchers have discovered a new cause for thyroid hormone deficiency, or hypothyroidism. The scientists identified a new hereditary form of hypothyroidism that is more prevalent in males than in females. This sex bias shone a light on where to look for the underlying cause.Mon, 12 Nov 2012 13:56:56 ESThttp://www.sciencedaily.com/releases/2012/11/121112135615.htmGenetic link between pancreatitis and alcohol consumptionhttp://www.sciencedaily.com/releases/2012/11/121112135520.htm A new study reveals a genetic link between chronic pancreatitis and alcohol consumption. Researchers found a genetic variant on chromosome X near the claudin-2 gene (CLDN2) that predicts which men who are heavy drinkers are at high risk of developing chronic pancreatitis.Mon, 12 Nov 2012 13:55:55 ESThttp://www.sciencedaily.com/releases/2012/11/121112135520.htmHumans are slowly but surely losing intellectual and emotional abilities, article suggestshttp://www.sciencedaily.com/releases/2012/11/121112135516.htm Human intelligence and behavior require optimal functioning of a large number of genes, which requires enormous evolutionary pressures to maintain. A provocative theory suggests that we are losing our intellectual and emotional capabilities because the intricate web of genes endowing us with our brain power is particularly susceptible to mutations and that these mutations are not being selected against in our modern society.Mon, 12 Nov 2012 13:55:55 ESThttp://www.sciencedaily.com/releases/2012/11/121112135516.htmHow chronic inflammation can cause cancerhttp://www.sciencedaily.com/releases/2012/11/121112135512.htm A new study has found that interleukin-15 (IL-15) alone can cause large granular lymphocytic (LGL) leukemia, a rare and usually fatal form of cancer. The researchers developed a treatment for the leukemia that showed no discernible side effects in an animal model. The study shows that IL-15 is also overexpressed in patients with LGL leukemia and that it causes similar cellular changes, suggesting that the treatment should also benefit people with the malignancy.Mon, 12 Nov 2012 13:55:55 ESThttp://www.sciencedaily.com/releases/2012/11/121112135512.htmList of diseases spread by deer tick grows, including malaria-like problems and potentially fatal encephalitishttp://www.sciencedaily.com/releases/2012/11/121112135510.htm An emerging tick-borne disease that causes symptoms similar to malaria is expanding its range in areas of the northeast where it has become well-established, according to new research.Mon, 12 Nov 2012 13:55:55 ESThttp://www.sciencedaily.com/releases/2012/11/121112135510.htmParkinson's disease: Compensation in the brain could lead to new treatmenthttp://www.sciencedaily.com/releases/2012/11/121112135404.htm New evidence indicates that Parkinson's disease is preceded by a period during which healthy regions of the brain take over the functions of damaged ones.Mon, 12 Nov 2012 13:54:54 ESThttp://www.sciencedaily.com/releases/2012/11/121112135404.htm

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